The NALM-6 mannequin, a priceless device in preclinical leukemia analysis, entails the implantation of human acute lymphoblastic leukemia cells into immunodeficient mice. This creates a residing system that mirrors the development and response to remedy seen in human leukemia, permitting researchers to check the illness and check potential remedies in a extra managed atmosphere.
This mannequin’s improvement offered researchers with a important platform for testing new therapies and learning leukemia improvement. It permits for detailed evaluation of illness development, drug resistance mechanisms, and the interplay between leukemia cells and the microenvironment. The power to check potential remedies in vivo earlier than medical trials gives a extra environment friendly and moral method to drug improvement, contributing to the development of leukemia remedy.